Beilstein J. Org. Chem.2018,14, 416–429, doi:10.3762/bjoc.14.30
these materials, in concert with DMC-mediated oxazoline formation as a final step, allow access to a selection of N-glycan oxazoline structures both in larger quantities and in a more expedient fashion than is achievable by total synthesis.
Keywords: DMC, ENGase; glycosyl oxazolines; N-glycans
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Graphical Abstract
Scheme 1:
The first ENGase-catalysed glycosylation of a GlcNAc acceptor using an N-glycan oxazoline as donor.